The Matrisome Project

The Matrisome Project is an effort initiated by Dr. Naba during her postdoctoral training in the laboratory of Dr. Richard Hynes at MIT, in collaboration with members of the Bioinformatics & Computing Facility at the Koch Institute for Integrative Cancer Research at MIT, and Karl Clauser and Steve Carr at the Proteomics Platform of the Broad Institute (Naba, Mol Cell Prot, 2023).

The Matrisome Project is an open access platform which aims to support and facilitate ECM research by sharing detailed protocols, tools and datasets with the scientific community.

Recent developments include:

- the development of the Matrisome Project website 

- the integration of quantitative proteomic data from the ECM Atlas in MatrixDB (Clerc et al., Nucleic Acids Research, 2019; Samarasinghe et al., Nucleic Acids Research, 2024).

- the deployment of MatrisomeDB, a searchable database of ECM proteomic datasets that provide live cross-referencing to gene and protein databases (Shao et al., Nucleic Acids Research, 2020 and Shao et al., Nucleic Acids Research, 2023).