New Publication: The cancer matrisome: from comprehensive characterization to biomarker discovery

Our latest review presents recent developments in computational and proteomic technologies that have led to the characterization of the ECM of tumors. These approaches have resulted in the definition of protein signatures distinguishing tumors from normal tissues, primary from secondary tumors, and tumors from other diseases such as fibrosis. We discuss recent studies that have demonstrated that the levels of expression of certain ECM genes is prognostic of cancer patient survival and can thus serve as biomarkers. We also discuss recent proteomic studies that have identified novel ECM proteins playing functional roles in cancer progression and thus have the potential to be exploited as therapeutic targets. Read our review here.