New publication: Proteomic profiling of the ECM of xenograft breast cancer metastases in different organs reveals distinct metastatic niches

In our latest study published in Cancer Research, we used quantitative mass spectrometry to analyze the ECM of triple-negative breast cancer metastases growing in the brain, lungs, liver and bone marrow. Our results show that both tumor and stromal cells cooperated in forming metastatic niches: stromal cells producing predominantly core, structural ECM proteins and tumor cells producing a diverse array of ECM-associated proteins. Additionally, we show that tumor and stromal cells together created distinct niches in different organs.